Rita Al-Moula
Lead laser aesthetician
- 20+ years in laser and skin treatments
Rita leads our laser hair removal team. Her career in laser and skin treatments spans more than two decades, during which she ran her own clinic and a VTCT training school.
Skin quality and under eyes
Polynucleotides in Canary Wharf
Rejuran and Plinest are injectable skin treatments that support your skin’s own repair. We use them to improve thin, dehydrated or crepey skin without adding volume.
Every treatment starts with a free consultation, in clinic or by video, including a free AI skin analysis. Our team checks the treatment is right for you and explains the risks.
From £395 per syringe See all prices
Polynucleotides at a glance
Book Free Consultation (opens our booking system in a new tab)- Products
- Rejuran and Plinest
- Treatment time
- Usually under an hour
- Course
- A course of sessions, then occasional top-ups
- Results
- Build gradually over the course
- Recovery
- Most people go straight back to their day
- Comfort
- Numbing cream can be applied first
- Areas
- Under eyes, face, neck and décolletage
- Price
- £395 per syringe
What are polynucleotides?
Polynucleotides are purified strands of DNA, usually sourced from fish, placed into the skin through a series of tiny injections. Rather than filling or freezing anything, they are meant to support the repair work your skin already does.
At Rejuvence we use them to improve skin quality: hydration, elasticity and the look of thin or crepey skin. They do not add volume, which is why they suit delicate areas such as under the eyes.
We offer two of the best-known polynucleotide brands. Rejuran, developed in South Korea, is used across the face and for skin texture. Plinest, made in Italy, has versions for the face and for the delicate skin around the eyes. Your practitioner recommends one based on your skin and the area being treated.
How the treatment works
Once in the skin, polynucleotides act as messengers that support tissue repair. They are thought to prompt fibroblasts (the cells that produce collagen) into action and to quieten the background inflammation that comes with older skin.
Because the treatment works through your own skin’s response, change is gradual. Improvement builds across a course of sessions, and occasional top-ups can help hold on to it.
Is it right for you?
It may suit you if
- You want to improve skin quality rather than change your features
- You have thin or crepey skin under the eyes or on the neck
- You are happy to have a course of treatments and wait for gradual results
It may not be suitable if
- You are pregnant or breastfeeding
- You have an active skin infection in the area
- You are allergic to fish or to any ingredient in the product
- You are looking for instant volume or a lift
If you have a medical condition or take regular medication, tell us at your consultation. We may ask you to speak to your GP first.
Risks and side effects
Polynucleotides are given by injection, so the usual effects of injections apply.
- Redness, swelling and tenderness where the needle went in
- Small raised bumps at the injection points for a short time
- Bruising, particularly under the eyes
- Rarely, infection or an allergic reaction
We explain the risks that apply to you at your consultation, along with what to do and who to contact if anything worries you afterwards.
Individual results vary. Results depend on your skin, age, lifestyle, the number of sessions and how closely you follow aftercare advice.
How it works
Your treatment, step by step
Free consultation
We look at your skin, talk through what you would like to change and check the treatment is right for you. It includes a free AI skin analysis, and you can come in or meet us by video.
Your plan and price
You get a clear plan: which areas, how many syringes and how many sessions, with the full price before you book.
Treatment
The area is cleansed and the polynucleotides are injected in small amounts.
Aftercare
You get written aftercare and a way to reach us if you have questions after your appointment.
Your free consultation includes an AI skin analysis. Not sure where to start? Try our AI consultation first.
Prices
Polynucleotides prices
Prices are per syringe. Your practitioner will tell you how many syringes and sessions your plan needs before you book treatment.
| Treatment | Price |
|---|---|
| Plinest, face (1 syringe) | £395 |
| Plinest Eye, under eyes (1 syringe) | £395 |
Prices correct as of November 2026. New patients book a free consultation before treatment. Prices are in pounds sterling.
Your practitioners
Who carries out your treatment
Rita Al-Moula, Kurt King and Dr Naeem Mitha look after every treatment at the clinic, from your first consultation to aftercare.
Kurt King
Aesthetician
- Level 4 Beauty Therapy
Kurt has trained in RF microneedling and on several of the clinic’s lasers, and builds every skin plan around the person in front of him. Many of our free skin consultations are with Kurt.
Dr Naeem Mitha
GP, leads our laser services
- MBBS
- BSc
- MRCGP
- PGDipClinDerm
Naeem is a practising GP who earned a postgraduate diploma in clinical dermatology with distinction. He leads the clinic’s laser work and carries out Aerolase assessments.
Questions
Polynucleotides questions
Anything else? Ask us at your free consultation, or call 020 7531 6600.
What are polynucleotides made from?
They are purified fragments of DNA, commonly derived from fish such as salmon or trout. Your practitioner will tell you which product is used and what it contains.
What is the difference between Rejuran and Plinest?
Both are polynucleotide treatments that aim to improve skin quality. They come from different manufacturers and each has its own range for different areas. We choose between them at your consultation, based on your skin and what you would like to improve.
How are polynucleotides different from fillers?
Dermal fillers add volume. Polynucleotides do not: they are used to improve the quality of the skin itself, such as hydration and elasticity, which is why they suit delicate areas like under the eyes.
How many appointments does a course involve?
Most people need a course of treatments because the improvement builds gradually. We will give you a plan at your consultation.
When will I see a difference?
This is a regenerative treatment, so change develops progressively over the course rather than straight away.
Does it hurt?
Most people find the injections manageable, and we check how you are feeling throughout.
Do polynucleotides work alongside other treatments?
Yes. They are often paired with laser treatment for under-eye pigmentation, or with Sylfirm X for texture. We will only suggest a combination if it suits your skin.
How much do polynucleotides cost?
Plinest costs £395 per syringe. Your consultation is free, and you will know the full price of your plan before you book treatment.
AI consultation
Unsure what to book? Let our AI consultation help
Answer a few quick questions in our AI consultation and it will suggest the treatments worth talking about. Then bring your shortlist to your free consultation.
Start the AI consultation
About two minutes. Nothing you choose is stored.
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Brands we use: Juvéderm
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Microneedling
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This page is general information, not medical advice. Treatments are for adults aged 18 and over. See our medical disclaimer.
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Free consultation
Thinking about polynucleotides?
Come in or meet us by video for a free consultation and AI skin analysis. We will tell you honestly whether the treatment suits you, and you leave with a clear plan and a full price.
Book Free Consultation (opens our booking system in a new tab)
In clinic or by video. Prefer to talk? Call 020 7531 6600